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Summary

My creative invention was the discovery and development of a new therapy to treat, and potentially eliminate, chronic hepatitis B virus (HBV) infection. I used the clinical stage drug ‘birinapant’ to specifically kill HBV infected liver cells by initiating a self-destruct signal in the host cells. Only infected cells are susceptible to this mode of killing. This is a completely novel innovation in the treatment of infectious diseases. My therapy cured HBV infection in preclinical models - something that has never been achieved before and this newly developed treatment is now in clinical trials. I am currently translating this breakthrough to the treatment of other overwhelming and chronic infectious diseases such as HIV infection and tuberculosis.

Description

Infectious diseases, collectively, cause more deaths and suffering than any other single disease. HBV alone has infected more than 2 billion people globally, including over 230,000 Australians. Chronic HBV infection causes liver cirrhosis and liver cancer, which is now the second leading cause of cancer related deaths. Currently, there is no cure for HBV infection. Standard therapies directly target the virus and reduce its capacity to replicate, but they never fully eliminate virus and hence the drugs must be taken lifelong. A cure is urgently required to mitigate the death and illness caused by chronic HBV infection.

I discovered that the drug ‘birinapant’ causes HBV infected liver cells to commit suicide, but it does not harm uninfected cells. This altruistic death of infected cells removes the reservoir of infection and completely eliminates virus in preclinical studies. I published this work in May 2015 and described the novel mechanism of action in two back-to-back papers [1,2]. My discovery progressed to Australian HBV clinical trials this year and the trial will expand into Asia in 2016 [3]. I am now translating this new and paradigm-shifting therapy [4] to treat other infections with high morbidity and mortality, such as HIV and tuberculosis (TB) that cause approximately 4 million deaths each year.

HIV and TB can hide and remain dormant in cells and then reactivate at anytime to cause disease. Accumulating data indicates that my treatment can preferentially kill these latently infected cells and prevent disease relapse. One third of the world’s population is latently infected with TB. People with dormant TB who receive immune suppressing drugs, such as those used to treat rheumatoid arthritis, can reactivate their infection and develop severe disease. My great hope is that the therapy I discovered is the “killer cure“ for many infections, including those caused by microbes that try to hide.

Additional Details

References

  1. Ebert G. et al., Cellular inhibitor of apoptosis proteins prevent clearance of hepatitis B virus. Proc Natl Acad Sci USA. 2015 May 5;112(18):5797-802. doi: 10.1073/pnas.1502390112.
  2. Ebert G. et al., Eliminating hepatitis B by antagonizing cellular inhibitors of apoptosis. Proc Natl Acad Sci USA. 2015 May 5;112(18):5803-8. doi: 10.1073/pnas.1502400112.
  3. http://www.lifescientist.com.au/towards-a-cure-for-hepatitis-b
  4. Lucifora J, Trepo C., Hepatitis: After HCV cure, HBV cure? Nat Rev Gastroenterol Hepatol. 2015 Jul;12(7):376-8. doi: 10.1038/nrgastro.2015.103.

Comments

BeckyGlass
19 days ago

I was diagnosed of Parkinson's disease following a neurological examination and other series of tests, my symptoms first appeared in February 2014 tremor in both limbs, rigid muscle, impaired posture.. all medication prescribed were not working and i sadly took off from my job, being a single mother with two kids it was almost a hopeless situation. In September 2016, i read about Health herbal clinic in a health forum, this herbal clinic have successful parkinson's disease herbal treatment and treatment for other list of terminal diseases, i contacted the herbal clinic via their website and purchased the parkinson's disease herbal remedy. I received the parkinson's disease herbal remedy via courier and immediately commenced usage. I used the remedy for 5 weeks, all my symptoms including tremor gradually dissapeared till i almost forgot i had the disease, i have started working again, thanks to Health herbal clinic. Visit www.healthherbalclinic.weebly.com or email healthherbalclinic@gmail.com Parkinson's disease is not a death sentence, don't die believing there is no cure, its a final breakthrough for all living with parkinson's disease

VickyHowarts
19 days ago

I am Vicky Howarts. I have looked for So many cure to cure my Herpes Disease, because i have suffered this deadly disease for more than 12years and i almost kill myself having this Disease, i was depressed, but i thank the Dr Ofemo for his help on my life today and i pray that God will continue to bless this herbal doctor for his rendering help on saving lives, i saw his testimonies on how he have cured so many people Herpes Virus ..i contacted him and asked for what to do to get my disease cured he told me what was needed to do and that was it he sent my herbal medicine to me and i receive it and used it after few days i saw changes and i decided to go to check myself and behold my result was negative. i can't be more than grateful to Dr Ofemo. for more information you are to contact his email:drofemospelltemple@gmail.com or his Mobile numbe: +2348163387496..i know many people are suffering from this same HERPES DISEASE and i want you to know that Dr Ofemo will help you just as he cured me.contact email:drofemospelltemple@yahoo.com

VickyHowarts
19 days ago

I am Vicky Howarts. I have looked for So many cure to cure my Herpes Disease, because i have suffered this deadly disease for more than 12years and i almost kill myself having this Disease, i was depressed, but i thank the Dr Ofemo for his help on my life today and i pray that God will continue to bless this herbal doctor for his rendering help on saving lives, i saw his testimonies on how he have cured so many people Herpes Virus ..i contacted him and asked for what to do to get my disease cured he told me what was needed to do and that was it he sent my herbal medicine to me and i receive it and used it after few days i saw changes and i decided to go to check myself and behold my result was negative. i can't be more than grateful to Dr Ofemo. for more information you are to contact his email:drofemospelltemple@gmail.com or his website: http://drofemospelltemple.wix.com/dr-ofemo or his Mobile numbe: +2348163387496..i know many people are suffering from this same HERPES DISEASE and i want you to know that Dr Ofemo will help you just as he cured me.contact email:drofemospelltemple@yahoo.com.

cynthia21
18 days ago

I am Cynthia I'm from Florida, I saw a comment posted by Jenny Louis from New York, on how she was free from skin cancer with CANNABIS OIL by Doctor Welma, I was diagnosed of HIV infections for the pass two years , I contacted Jenny Louis and she told me that this very doctor cures Cancer,Herpes and more Disease and he also cures HIV/AIDS too, then i contacted Doctor Welma, so he told me what to do to get healing and free from HIV, so I make provisions for the HERBAL CREAM which i used for three weeks and now just to see that the exact weeks which doctor Welma told me I will be healed i was feeling good and healthy, my skin regained, I went for check up in the hospital and my Doctor told me that all the virus disappeared from my blood vessels and normal, then i made a promise to Doctor that I will testify of his good herbal medicine to the world, so I will like you to contact him on (drwelmacoleherpescure@gmail.com or whatsapp him +2348086469340 if you have any health issue i believe Doctor Welma will help you..PLEASE HELP ME TO THANK HIM

jessical
15 days ago

ALL THANKS TO DR WILLIAMS FOR CURING ME FROM A DEADLY DISEASE HEPATITIS B.
Appreciation is the key to doing more that is why I have took some
time out to thank some one who cured me of my 2 years HEPATITIS B
problem. It became a major problem to me as it was affecting my
marital life and I was no longer comfortable so I decided to look for
a solution and I came across a post of Dr willaims and how he has been
helping people of the same problem I contacted him and told him all I
have been facing in my life. He told me how to get his product and how
to take it after every thing I find out that all was now okay with me
and that my HEPATITIS B problem was gone that is why I have come out
today to say thank you to him . his email address drwilliams098765@gmail.com for advice and for his product

jessical
15 days ago

ALL THANKS TO DR WILLIAMS FOR CURING ME FROM A DEADLY DISEASE HEPATITIS B.
Appreciation is the key to doing more that is why I have took some
time out to thank some one who cured me of my 2 years HEPATITIS B
problem. It became a major problem to me as it was affecting my
marital life and I was no longer comfortable so I decided to look for
a solution and I came across a post of Dr willaims and how he has been
helping people of the same problem I contacted him and told him all I
have been facing in my life. He told me how to get his product and how
to take it after every thing I find out that all was now okay with me
and that my HEPATITIS B problem was gone that is why I have come out
today to say thank you to him . his email address drwilliams098765@gmail.com for advice and for his product 0987

amelidasophia
7 days ago

I am very happy today to share this amazing testimony on how Dr. idahosa the herbal doctor was able to cure me from my HIV Virus with his herbal medicine. I have been a HIV patient for almost 8 months now and have tried different methods of treatment to ensure that I am cured of this terrible disease, but none worked for me, so I had to leave everything to God to handle as I was a Christian who had faith that one day God would intervene in my life, yet I felt so sad and desperate as I was losing almost everything due to my illness, A few months ago while I was surfing the internet I saw different recommendation about Dr idahosa on how he have been using his herbal Medicine to treat and cure people, these people advice we contact Dr. idahosa for any problem that would help immediately, I contacted Dr idahosa and I told him how I got his contact and also about my disease, after some time Dr. idahosa told me to have faith that he would prepare for me a medication of herbal herbs, he told me I would take this medicine for a few weeks and also asked my home for home address so as possible for him to submit the drug for me, so my good friends after all the process and everything Dr idahosa actually sent me the medicine, I took it as I was directed by Dr. idahosa, after a few weeks passed, while on Dr.idahosa medication I began to experience changes in my body, I had to call my doctor at the hospital for some blood test after test my hospital doctor told me that I was no longer with the Hiv virus and my blood is pretty good, I can not even believe this, Friends well today i am Hiv Free and i want everyone to know that there is a cure for Hiv for those who will contact Dr idahosa after reading my testimony, you can kindly contact Dr. idahosa in (dridahosasolutioncenter@gmail.com) or call him +2348134261542, God bless you all ...

USMANpinda
5 days ago

My name is pineda from CALIFORNIA . few months back I was diagnosed with HERPES virus, I felt so depressed because I knew that their was no cure (solution) to it, it was so hard to share with my Family, but I couldn't help it than to discuss it with my wife because the issue was already getting out of hands, I and my wife started looking for answers to the problem, we have visited so my hospital for help but to no avail. On this faithful morning my wife called me and told me she came across a comment on social media and it was talking about how a doctor cured a lady of her HIV VIRUS and some other talking about herpes cure, I was amazed because I knew HIV VIRUS was hard to cure...so I said to her can the doctor have answers to my problems too?,in the other hands there was no harm in trying so I and my wife agreed in contacting the doctor for help, DR atukema is a true heavenly sent to cure me, in no time I sent an email to him and he gave me all the details i need now am happy and cured from herpes virus all thanks to dr atukema for his awsome work for me if you are similar problem like mine you can contact doctor on him email via
dr.atukema@gmail.com or WHATSAPP VIA +2347064693371
THANK YOU AND GOD BLESS
dr.atukema@gmail.com
whatsapp.....+2347064693371

twnnaclyton
5 days ago

I have been suffering from (HERPES) disease for the last four years and had constant pain, especially in my knees. During the first year,I had faith in God that i would be healed someday.This disease started circulate all over my body and i have been taking treatment from my doctor, few weeks ago i came on search on the INTERNET if i could get any information concerning the prevention of this disease, on my search i saw a testimony of someone who has been healed from (Hepatitis B and Cancer) by this Man Dr Gumbla and she also gave the email address of this man and advise we should contact him for any sickness that he would be of help, so i wrote to Dr Gumbla telling him about my (HERPES Virus) he told me not to worry that i was going to be cured!! hem i never believed it,, well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me as the Dr assured me that i have cured,after some time i went to my doctor to confirmed if i have be finally healed behold it was TRUE, So friends my advise is if you have such sickness or any other at all you can email Dr Gumbla on : (greatgumblaspellhome@outlook.com) or thought his website http://eromosalspiritualtemple.webs.com or call or what'sapp him with +2348161850195.. THESE ARE THE THINGS DR GUMBALA CAN ALSO CURE.. GONORRHEA, HIV/AIDS , LOW SPERM COUNT, MENOPAUSE DISEASE, PREGNANCY PROBLEM, SHORT SIGHTEDNESS PROBLEM, Stroke, Bring back ex lover or wife/husband....sir i am indeed grateful for the help i will forever recommend you to my friends!!

celina55
1 day ago

2016 november i was diagnosed with hepatitis b .i was given lamivudine (Epivir) as medication to slow its ability to damage my liver,but i was not satisfy ,i wanted a permanent cure ,my wife friend told us about hepatitis b herbal medicine she purchased online from perfect health herbal medicine home,and said she was cured within 35days,so my wife decided to purchase for me too,i used the herbal medicine for 5 weeks,then went for medical check up which my family doctor confirmed am hepatitis b free. Thanks to perfect health herbal medicine.
contact them on perfecthealthherbalmedicine@gmail.com. website www.perfecthealthherbal.weebly.com or call them +1-586-501-6759

priyasoylu23
about 10 hours ago

Hello everyone I'm here to appreciate the great work Dr Ojie how he cured my Herpes Disease, that almost took my life, i have lived with this disease and did all i could be cured but no way.i have been searching out on a cure to terminate my Herpes and on my search i found Dr Ojie help on the lives of many people . and after i wrote to him on how to get a cure, he directed me on the steps and he prepared my herbal medicine and after he sent it to me that after using it, i will be cured, and that was how he sent me my medicine and after using it for some days i was found negative by my test result. why not contact him today on his email:{ drojiespelltemple@gmail.com } Or check his website: https://drojiespelltemple.wixsite.com/spelltemple or call +2348105074556 thanks you

priyasoylu23
about 10 hours ago

Hello everyone I'm here to appreciate the great work Dr Ojie how he cured my Herpes Disease, that almost took my life, i have lived with this disease and did all i could be cured but no way.i have been searching out on a cure to terminate my Herpes and on my search i found Dr Ojie help on the lives of many people . and after i wrote to him on how to get a cure, he directed me on the steps and he prepared my herbal medicine and after he sent it to me that after using it, i will be cured, and that was how he sent me my medicine and after using it for some days i was found negative by my test result. why not contact him today on his email:{ drojiespelltemple@gmail.com } Or check his website: https://drojiespelltemple.wixsite.com/spelltemple or call +2348105074556 thanks you .....

walthermorris
about 7 hours ago

HOW I GOT CURED FROM HERPES VIRUS I was diagnosed of HERPES Virus in 2015
and I have tried all I can to get cured but all to no avail, until i saw a post in a health forum about a herbalist man who prepare herbal medication to cure all kind of diseases including HERPES virus, at first i doubted if it was real but decided to give it a try , when i contact this herbalist via his email and he prepared a HERPES herbal cure and sent it to me via UPS delivery company service, when i received this herbal cure, he gave me step by directions on how to apply it, when i applied it as instructed, i was totally cured of this deadly disease within 14days of usage, I am now free from the deadly disease called herpes, all thanks to DR.ERAZUA. Contact this great herbal doctor via his email dr.erazuagreattemple@gmail.com or dr.erazuagreattemple@hotmail.com call or whatsapp him on his mobile number (+2349060424123)..his Facebook page website http://facebook.com/Erazuaspellcaster and if you want to know more about this great DR, you can visit his website http://drerazuagreattempl.wixsite.com/dr-erazua

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